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Fatigue, inflammation, and projected mortality in heart failure
Anne M Fink1, Rosalia C Gonzalez, Tadeusz Lisowski
1Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA. afink2@uic.edu
Journal of Cardiac Failure
|September 4, 2012
Summary
Fatigue in heart failure with reduced ejection fraction (HFrEF) is linked to depression. This study found fatigue correlates with poorer prognosis, not immune markers, in HFrEF patients.
Area of Science:
- Cardiology
- Immunology
- Psychiatry
Background:
- Fatigue is a significant, poorly understood symptom in heart failure with reduced ejection fraction (HFrEF).
- Understanding the relationship between fatigue, immune biomarkers, and prognosis in HFrEF is crucial for patient management.
Purpose of the Study:
- To investigate correlations between fatigue and immune biomarkers in HFrEF patients.
- To determine if fatigue is associated with prognosis in HFrEF.
Main Methods:
- Prospective study of 59 HFrEF patients and 25 healthy controls.
- Assessed fatigue, depressive symptoms, sleep quality, and immune biomarkers (CRP, TNF-α, IL-6, IL-10).
- Calculated Seattle Heart Failure Model (SHFM) mortality risk scores.
Main Results:
- HFrEF patients reported significantly higher fatigue, depressive symptoms, and poorer sleep quality than controls.
- After adjusting for depressive symptoms, fatigue levels did not differ between HFrEF patients and controls.
- Fatigue was significantly associated with higher SHFM scores, indicating a poorer prognosis, but did not correlate with immune biomarkers.
Conclusions:
- Depressive symptoms are a significant factor influencing fatigue perception in HFrEF.
- This study is the first to demonstrate a positive association between fatigue and prognosis in HFrEF patients, as indicated by SHFM scores.
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