Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 19, 2026

Microfabricated Platforms for Mechanically Dynamic Cell Culture
15:21

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

Engineering surface adhered poly(vinyl alcohol) physical hydrogels as enzymatic microreactors.

Betina Fejerskov1, Bettina E B Jensen, Najah B S Jensen

  • 1Department of Chemistry, Aarhus University, Denmark.

ACS Applied Materials & Interfaces
|September 4, 2012
PubMed
Summary

Researchers developed novel poly(vinyl alcohol) hydrogels for targeted drug delivery. These intelligent biointerfaces enable controlled release of anticancer drugs via a new Substrate Mediated Enzyme Prodrug Therapy (SMEPT) approach.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Broad-Spectrum Antimicrobial Treatment Targeted Through Drug Conjugation to Vancomycin.

Advanced healthcare materials·2025
Same author

Activation of enzymatic catalysis via nucleic acid hybridization affords synergistic coupling of specificity, potency, and signal amplification.

Nature communications·2025
Same author

Artificial Internalizing Receptors for Targeted Degradation of Extracellular Proteins.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Artificial Biology - Assemble, Imitate, Adapt.

Advanced biology·2025
Same author

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells.

Bioconjugate chemistry·2025
Same author

Artificial Internalizing Receptors: Intracellular Delivery of Cargo Through Bio-Orthogonal Recognition.

Advanced healthcare materials·2024

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Surface Chemistry

Background:

  • Poly(vinyl alcohol) (PVA) hydrogels are versatile biomaterials.
  • Surface-mediated drug delivery requires advanced biointerfaces.
  • Controlling hydrogel properties is crucial for biomedical applications.

Purpose of the Study:

  • To characterize physical hydrogels of PVA as intelligent biointerfaces for surface-mediated drug delivery.
  • To investigate the use of sodium sulfate (Na(2)SO(4)) for assembling microstructured (μS) PVA hydrogels.
  • To develop and assess a novel Substrate Mediated Enzyme Prodrug Therapy (SMEPT) using these hydrogels.

Main Methods:

  • Noncryogenic gelation of PVA using varying concentrations of sodium sulfate.
  • Quantification of PVA loss and retention using a custom thiol-functionalized PVA and UV-vis assay.

More Related Videos

Synthesis of an Intein-mediated Artificial Protein Hydrogel
15:06

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Published on: January 27, 2014

Methods for Embedding Cell-Free Protein Synthesis Reactions in Macro-Scale Hydrogels
06:38

Methods for Embedding Cell-Free Protein Synthesis Reactions in Macro-Scale Hydrogels

Published on: June 23, 2023

Related Experiment Videos

Last Updated: May 19, 2026

Microfabricated Platforms for Mechanically Dynamic Cell Culture
15:21

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

Synthesis of an Intein-mediated Artificial Protein Hydrogel
15:06

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Published on: January 27, 2014

Methods for Embedding Cell-Free Protein Synthesis Reactions in Macro-Scale Hydrogels
06:38

Methods for Embedding Cell-Free Protein Synthesis Reactions in Macro-Scale Hydrogels

Published on: June 23, 2023

  • Characterization of hydrogel elasticity and application in cell culture and drug delivery.

    • Main Results:

    • Systematic control over μS PVA hydrogel assembly and elasticity was achieved by varying Na(2)SO(4) concentrations.
    • A facile UV-vis assay was established for accurate polymer quantification.
    • The μS PVA hydrogels successfully functioned as reservoirs for enzymatic cargo in SMEPT, enabling anticancer drug delivery to adhered hepatic cells.

    Conclusions:

    • PVA hydrogels assembled via sodium sulfate-induced coagulation offer tunable elasticity for biointerfaces.
    • The developed SMEPT approach demonstrates effective surface-mediated delivery of anticancer drugs.
    • These findings advance the development of novel matrices for drug delivery and biomedical applications.