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Auditory neuropathy in a low-risk population: a review of the literature

A M H Korver1, G A van Zanten, A Meuwese-Jongejeugd

  • 1Willem-Alexander Children's Hospital, Sub Department of Social Pediatrics, Leiden University Medical Center, The Netherlands. a.m.h.korver@lumc.nl

International Journal of Pediatric Otorhinolaryngology
|September 4, 2012
PubMed

Insights

Auditory neuropathy is missed in newborn hearing screenings using oto-acoustic emissions, contributing 4-17% to false negatives. More research is needed on auditory brainstem response screening effectiveness.

Area of Science:

  • Neonatal screening
  • Auditory health
  • Neurology

Background:

  • Auditory neuropathy (AN) is a hearing disorder affecting the auditory nerve.
  • Newborn hearing screening programs aim to detect hearing loss early.
  • Oto-acoustic emissions (OAEs) are commonly used in initial screening.

Purpose of the Study:

  • To determine the prevalence of auditory neuropathy in well babies.
  • To quantify the impact of auditory neuropathy on the false negative rate of OAE-based newborn hearing screening.

Main Methods:

  • Systematic literature search of PubMed and EMBASE (1996-2010).
  • Inclusion of original studies reporting AN prevalence in well infants.
  • Analysis of data to calculate the false negative rate attributed to AN.

Main Results:

  • Four studies met inclusion criteria.
  • Prevalence of AN in screened infants ranged from 0.006% to 0.03%.
  • AN accounted for 4-17% of false negatives in OAE-based screening.

Conclusions:

  • Current data on AN prevalence in infants is limited.
  • OAE screening may miss infants with auditory neuropathy.
  • Cost-effectiveness of auditory brainstem response (ABR) screening warrants investigation.
Abstract

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