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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...

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Updated: May 19, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

[Palindromic rheumatism].

M Vayssade1, Z Tatar, M Soubrier

  • 1Service de rhumatologie, hôpital Gabriel-Montpied, CHU de Clermont-Ferrand, 58, boulevard Montalembert, BP 69, 63003 Clermont-Ferrand cedex 1, France.

La Revue De Medecine Interne
|September 4, 2012
PubMed
Summary
This summary is machine-generated.

Palindromic rheumatism involves recurring arthritis episodes without lasting damage. It may evolve into rheumatoid arthritis or be linked to autoinflammatory diseases, with antimalarials potentially delaying progression.

Related Experiment Videos

Last Updated: May 19, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Background:

  • Palindromic rheumatism presents as episodic arthritis without permanent joint changes.
  • Differential diagnosis is crucial to exclude other conditions.
  • Progression to rheumatoid arthritis is observed, particularly in seropositive individuals.

Purpose of the Study:

  • To explore the nature of palindromic rheumatism.
  • To investigate its relationship with rheumatoid arthritis and autoinflammatory diseases.
  • To discuss treatment strategies.

Main Methods:

  • Literature review and clinical observation analysis.
  • Review of diagnostic criteria and differential diagnoses.
  • Analysis of treatment outcomes, including antimalarial use.

Main Results:

  • Palindromic rheumatism can evolve into rheumatoid arthritis, especially with positive rheumatoid factor and anticitrullinated peptides.
  • In seronegative cases, palindromic rheumatism may be associated with autoinflammatory diseases due to MEFV mutations.
  • Antimalarials may hinder the development of rheumatoid arthritis or other connective tissue diseases.

Conclusions:

  • Palindromic rheumatism requires careful diagnosis to differentiate from other arthritic conditions.
  • Its potential link to autoinflammatory diseases highlights the importance of genetic factors (MEFV mutations).
  • Antimalarial therapy is a potential strategy to manage palindromic rheumatism and prevent disease progression.