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Abnormal vascular architecture at the placental-maternal interface in placenta increta
Frédéric Chantraine1, Silvia Blacher, Sarah Berndt
1Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire, Hôpital la Citadelle, Liège, Belgium. fchantraine@chu.ulg.ac.be
Objective:
The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies.
Study Design:
Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections.
Results:
The total areas occupied by vessels in normal and placenta-increta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta-vessel distributions (area and distance from the placental-myometrial junction) were more heterogeneous.
Conclusion:
Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.
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