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Metabolic master regulators: sharing information among multiple systems.

Barbara E Corkey1, Orian Shirihai

  • 1Obesity Research Center, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. bcorkey@bu.edu

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Obesity and diabetes stem from metabolic tissue defects. A new model proposes that the redox metabolome coordinates these tissues via circulation, suggesting a unified regulatory approach for metabolic homeostasis.

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Area of Science:

  • Metabolic physiology
  • Endocrinology
  • Systems biology

Background:

  • Obesity and diabetes are linked to metabolic tissue dysfunction.
  • Insulin resistance is a primary focus, with research concentrating on signal transduction pathways.
  • Each tissue plays a role in metabolic homeostasis, potentially contributing to obesity and diabetes.

Purpose of the Study:

  • To investigate the role of the redox metabolome in coordinating metabolic tissue responses.
  • To explore a model where metabolic pathosis arises from the collective contribution of multiple tissues.
  • To examine the concept of a circulating communication system regulating metabolic homeostasis.

Main Methods:

  • Focus on the redox metabolome as a coordinating system.
  • Consideration of a circulating communication system between metabolic tissues.
  • Modeling the integrated response of multiple tissues to metabolic challenges.

Main Results:

  • The redox metabolome is central to coordinating tissue responses and reflects shared regulatory control.
  • Evidence supports a model where metabolic diseases result from the interplay of multiple tissues.
  • A circulating communication system may link and regulate all collaborating metabolic organs.

Conclusions:

  • The redox metabolome is a key regulator of metabolic homeostasis across different tissues.
  • Metabolic diseases like obesity and diabetes may arise from dysregulation within a coordinated system of metabolic tissues.
  • Targeting this circulating communication system could offer a unified approach to managing metabolic disorders.