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Related Experiment Videos

A decrease in opioid tone amplifies the luteinizing hormone surge in estrogen-treated ovariectomized rats:

C Masotto1, A Sahu, M G Dube

  • 1Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610.

Endocrinology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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The neural clock

Area of Science:

  • Neuroendocrinology
  • Reproductive Biology
  • Hormonal Regulation

Background:

  • Estrogen-induced LH surge in ovariectomized (ovx) rats is typically smaller than natural surges.
  • The neural clock (NC) is known to reduce hypothalamic opioid tone, inducing the preovulatory LH surge.
  • A diminished reduction in opioid tone might explain the weaker estrogen-induced LH surge in ovx rats.

Purpose of the Study:

  • To investigate if inadequate reduction in hypothalamic opioid tone causes the diminished estrogen-induced LH surge in ovx rats.
  • To examine the effect of naloxone (NAL), an opiate receptor antagonist, on LH secretion in estrogen-primed ovx rats.
  • To compare NAL-induced LH surges with progesterone (P)-induced surges and natural preovulatory surges.

Main Methods:

  • Ovariectomized rats were primed with either estradiol implants or estradiol benzoate (EB) injections.

Related Experiment Videos

  • Naloxone (NAL) was infused intravenously to transiently decrease opioid tone.
  • LH levels were measured, and comparisons were made with progesterone (P) treatment and previous natural surge data.

    • Main Results:

    • Estrogen alone caused a modest spontaneous LH rise.
    • NAL infusion significantly enhanced LH surges in both short-term and long-term ovx rats.
    • In long-term ovx rats, NAL-induced LH surges were comparable to those induced by P and natural preovulatory surges.
    • NAL accelerated the frequency and amplitude of episodic LH secretion.

    Conclusions:

    • Transiently decreasing inhibitory opioid tone with NAL can restore preovulatory-type LH surges in estrogen-treated ovx rats.
    • This suggests that the neural clock's reduction of opioid tone may be insufficient in estrogen-treated rats.
    • Progesterone and NAL likely enhance LH surges by further reducing opioid tone, mimicking the preovulatory surge.