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Related Experiment Video

Updated: May 19, 2026

Optimization of Radiochemical Reactions using Droplet Arrays
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Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Optimization of [11C]DASB-synthesis: vessel-based and flow-through microreactor methods.

Johanna Ungersboeck1, Cecile Philippe, Daniela Haeusler

  • 1Radiochemistry and Biomarker Development Unit, Department of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|September 4, 2012
PubMed
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Researchers aimed to develop a microfluidic system for N-(11)C-methylations using carbon-11 labeled methyl iodide and methyl triflate. While the microfluidic setup was not achieved, routine production of [(11)C]DASB was optimized.

Area of Science:

  • Radiochemistry
  • Chemical Engineering
  • Nuclear Medicine

Background:

  • N-(11)C-methylation is a crucial step in synthesizing various positron emission tomography (PET) tracers.
  • Current methods often rely on vessel-based synthesis, which can be time-consuming.
  • Microfluidic systems offer potential for faster and more efficient radiopharmaceutical production.

Purpose of the Study:

  • To implement a microfluidic setup for N-(11)C-methylations using a flow-through microreactor.
  • To evaluate [(11)C]DASB as a model compound for this microfluidic synthesis.
  • To investigate [(11)C]CH(3)I and [(11)C]CH(3)OTf as (11)C-methylation agents in the microreactor.

Main Methods:

  • Attempted implementation of a microfluidic flow-through reactor for N-(11)C-methylation.

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Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

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Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
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Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

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Last Updated: May 19, 2026

Optimization of Radiochemical Reactions using Droplet Arrays
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Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
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Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
09:50

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Published on: April 28, 2019

  • Utilized [(11)C]DASB as the model compound.
  • Employed [(11)C]CH(3)I and [(11)C]CH(3)OTf as (11)C-methylation agents.

    • Main Results:

    • The microfluidic setup for N-(11)C-methylation was not successfully implemented due to an observed "aging" effect of the (11)C-methylation agents.
    • Despite the challenges, observations led to optimization of the vessel-based routine production of [(11)C]DASB.
    • Routine production time was reduced to 34±1 min.
    • Radiochemical yield (RCY) was increased to 45.1±4.6% (end of bombardment; EOB).

    Conclusions:

    • Direct implementation of the intended microfluidic N-(11)C-methylation was hindered by agent instability.
    • The study provided valuable insights into the stability of (11)C-methylation agents.
    • Optimized vessel-based synthesis of [(11)C]DASB achieved improved efficiency and yield, demonstrating progress in radiotracer production.