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Angiogenin in middle-aged type 1 diabetes patients
Jolanta Neubauer-Geryk1, Grzegorz M Kozera, Bogumil Wolnik
1Department of Clinical Physiology, Medical University of Gdansk, Debinki 7 Street, 80-211 Gdansk, Poland. jolaneub@gumed.edu.pl
Microvascular Research
|September 4, 2012
Summary
Serum angiogenin levels are lower in middle-aged adults with type 1 diabetes compared to controls. However, higher angiogenin levels are observed in those with diabetic nephropathy or a smoking habit.
Area of Science:
- Endocrinology
- Vascular Biology
- Diabetology
Background:
- Angiogenin levels are elevated in pediatric patients with type 1 diabetes.
- Limited data exists on angiogenin concentrations in adult type 1 diabetes patients.
- This study investigates angiogenin in middle-aged adults with type 1 diabetes and microvascular complications.
Purpose of the Study:
- To determine serum angiogenin concentrations in middle-aged adults with type 1 diabetes.
- To compare angiogenin levels between type 1 diabetes patients and age-matched controls.
- To explore the association between angiogenin levels and diabetic nephropathy, retinopathy, and neuropathy.
Main Methods:
- Cross-sectional study involving 57 middle-aged adults with type 1 diabetes and 38 age-matched controls.
- Data collection included medical histories, assessment of microangiopathy, and measurement of serum angiogenin concentrations.
- Statistical analysis compared angiogenin levels between groups and subgroups.
Main Results:
- Serum angiogenin levels were significantly lower in type 1 diabetes patients (384.2 ng/ml) compared to controls (460.4 ng/ml) (p=0.04).
- Patients with overt diabetic nephropathy exhibited higher angiogenin levels than those without nephropathy (p=0.01).
- Smokers with type 1 diabetes had higher angiogenin levels than non-smokers (p=0.01), but no differences were found for other microvascular complications.
Conclusions:
- Middle-aged type 1 diabetes patients have lower serum angiogenin levels than controls, irrespective of microangiopathy.
- Overt diabetic nephropathy and smoking are associated with elevated angiogenin levels in this population.
- Further research may elucidate the role of angiogenin in type 1 diabetes complications.
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