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Related Experiment Video

Updated: May 19, 2026

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

Ex-vivo lung perfusion.

Pablo G Sanchez1, Frank D'Ovidio

  • 1Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Current Opinion in Organ Transplantation
|September 4, 2012
PubMed
Summary
This summary is machine-generated.

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Ex-vivo lung perfusion (EVLP) helps identify suitable lungs from donors initially deemed unsuitable for transplantation. This technique also shows promise for evaluating new therapies to reduce transplant complications.

Area of Science:

  • Thoracic surgery
  • Transplantation immunology
  • Organ preservation

Background:

  • Lung transplantation is limited by donor organ availability.
  • Ex-vivo lung perfusion (EVLP) allows reassessment of initially unsuitable donor lungs.
  • EVLP provides a controlled environment for organ evaluation.

Purpose of the Study:

  • To review recent clinical and research findings on EVLP.
  • To summarize the utility of EVLP in lung transplantation.
  • To highlight EVLP's role in donor lung assessment.

Main Methods:

  • Review of recent clinical reports and research studies on EVLP.
  • Analysis of data from centers utilizing EVLP for donor lung selection.
  • Synthesis of findings on post-transplant outcomes with EVLP-assessed lungs.

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Isolated Lung Perfusion System in the Rabbit Model
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Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
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Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation

Published on: September 29, 2023

Related Experiment Videos

Last Updated: May 19, 2026

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

Isolated Lung Perfusion System in the Rabbit Model
10:18

Isolated Lung Perfusion System in the Rabbit Model

Published on: July 15, 2021

Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
05:49

Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation

Published on: September 29, 2023

Main Results:

  • EVLP successfully identifies viable grafts from higher-risk donors.
  • Post-transplant outcomes using EVLP-selected lungs are comparable to standard criteria donors.
  • EVLP serves as a platform to mitigate ischemia-reperfusion injury.

Conclusions:

  • EVLP is a valuable tool for selecting suitable lungs from rejected donors.
  • EVLP demonstrates potential as a platform for evaluating novel therapeutics.
  • EVLP enhances the utilization of donor lungs for transplantation.