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Nanostructured substrate conformation can decrease osteoblast-like cell dysfunction in simulated microgravity

Ljupcho Prodanov1, Jack J W A van Loon, Joost te Riet

  • 1Department of Biomaterials, Radboud University Nijmegen Medical Centre, The Netherlands.

Journal of Tissue Engineering and Regenerative Medicine
|September 4, 2012
PubMed
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Nanotextured surfaces and simulated microgravity influence bone precursor cell behavior. Combining these conditions reversed negative effects on cell number and alkaline phosphatase activity, suggesting a protective role for nanotextures.

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Mechanobiology

Background:

  • Cells respond to the extracellular matrix (ECM) and mechanical forces.
  • Understanding cell morphology regulation is crucial for tissue engineering.

Purpose of the Study:

  • To model multifactorial influences on cell morphology.
  • To investigate the combined effects of nanotextured substrates and simulated microgravity on bone precursor cells.

Main Methods:

  • Rat bone marrow-derived cells cultured on nanotextured polystyrene (200 nm pitch, 50 nm depth).
  • Simulated microgravity applied using a random positioning machine (RPM).

Main Results:

  • Cells aligned with nanotextures; simulated microgravity caused partial re-alignment.
Keywords:
nanotextureosteoblast-like cellssimulated microgravitytissue remodelling

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  • Nanotextured substrate increased cell number and alkaline phosphatase (ALP) activity.
  • Simulated microgravity decreased cell number and ALP activity, but this was reversed by combining with nanotextures.

    • Conclusions:

    • Absence of mechanical load (simulated microgravity) negatively impacts early osteoblastogenesis.
    • Nanotextured surfaces can partially counteract the negative effects of simulated microgravity on bone precursor cells.