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Updated: May 19, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

Nitric oxide-mediated coronary flow regulation in patients with coronary artery disease: recent advances

Noboru Toda, Shinichi Tanabe, Sadanobu Nakanishi

    The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
    |September 4, 2012
    PubMed

    Insights

    Nitric oxide (NO) from endothelial NO synthase (eNOS) is vital for heart health, preventing blockages and promoting blood flow. Addressing factors that impair endothelial function is key to preventing coronary artery disease.

    Area of Science:

    • Cardiovascular Science
    • Endothelial Biology
    • Nitric Oxide Signaling

    Background:

    • Endothelial nitric oxide (NO) produced by endothelial NO synthase (eNOS) is critical for regulating coronary blood flow, inhibiting platelet aggregation, and preventing thrombosis and atherosclerosis.
    • Endothelial dysfunction, characterized by reduced NO bioavailability and increased oxidative stress, is linked to risk factors like smoking, obesity, and hypertension.
    • Endothelial dysfunction is a significant predictor of coronary artery disease (CAD) and is associated with conditions like atrial fibrillation and penile erectile dysfunction.

    Purpose of the Study:

    • To highlight the crucial role of endothelial NO in cardiovascular health.
    • To identify key factors and mechanisms contributing to endothelial dysfunction.
    • To emphasize the predictive value of endothelial dysfunction for cardiovascular diseases.

    Main Methods:

    • Review of existing literature on nitric oxide synthase (NOS) pathways.
    • Analysis of factors affecting endothelial function.
    • Correlation of endothelial dysfunction with cardiovascular and other health conditions.

    Main Results:

    • Endothelial NO synthase (eNOS) activity is essential for vasodilation and preventing platelet aggregation.
    • Pathogenic factors such as smoking, hypercholesterolemia, and hypertension impair endothelial function.
    • Endothelial dysfunction predicts coronary artery disease and is linked to penile erectile dysfunction.

    Conclusions:

    • Maintaining endothelial function through prophylactic and therapeutic interventions is crucial for preventing coronary artery disease.
    • Addressing nitrergic nerve dysfunction is important for cardiovascular health.
    • Understanding the mechanisms of endothelial dysfunction can guide the prevention and treatment of CAD.

    Keywords:
    Nitric oxideasymmetric dimethylarginineconstitutive nitric oxide synthasecoronary artery diseasecoronary blood flowendothelial dysfunction

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