Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Esophageal Varices-II: Clinical Features and Management

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Short term safety and efficacy of robot-assisted laparoscopic redo hiatal hernia repair without mesh: a retrospective cohort study.

Journal of thoracic disease·2026

Same author

Statewide Medicaid Expansion and Survival in Resectable Non-Small Cell Lung Cancer.

JAMA network open·2025

Same author

Surgical outcomes of smoking and nonsmoking women with lung adenocarcinoma.

Journal of thoracic disease·2025

Same author

Esophageal reconstruction using a hypopharyngeal anastomosis - a single center experience with review of the literature.

Journal of cardiothoracic surgery·2025

Same author

Glimpse of Hope for Patients with Oligometastatic Lung Cancer.

Journal of the American College of Surgeons·2025

Same author

Robotic hiatal hernia repair without mesh.

Journal of thoracic disease·2024

Search research articles

Related Experiment Video

Updated: May 19, 2026

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

TRALI Syndrome Complicated by Retroperitoneal Bleeding.

Vijay A Singh¹, David Zeltsman

¹Division of Cardiothoracic Surgery, Department of Surgery, North Shore-Long Island Jewish Hospital Systems, New York.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc

|September 4, 2012

Summary

Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusions. This case highlights TRALI

Keywords:

Transfusion lung injury pulmonary atresia retroperitoneal hematoma

More Related Videos

Surgical Trunk Oriented Laparoscopic Right Hemicolectomy (ST-LRH) for Right-Sided Colon Cancer

Surgical Trunk Oriented Laparoscopic Right Hemicolectomy (ST-LRH) for Right-Sided Colon Cancer

Published on: July 25, 2025

Related Experiment Videos

Last Updated: May 19, 2026

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

Surgical Trunk Oriented Laparoscopic Right Hemicolectomy (ST-LRH) for Right-Sided Colon Cancer

Surgical Trunk Oriented Laparoscopic Right Hemicolectomy (ST-LRH) for Right-Sided Colon Cancer

Published on: July 25, 2025

Area of Science:

Critical Care Medicine
Hematology
Cardiovascular Surgery

Background:

Transfusion-related acute lung injury (TRALI) is a significant cause of transfusion-related mortality, often underdiagnosed.
TRALI incidence ranges from 1 in 2000 to 5000 transfusions, with high mortality when combined with severe bleeding.

Observation:

A 25-year-old male with congenital heart disease and pulmonary atresia developed hemoptysis requiring pneumonectomy.
During surgery, severe bleeding from the superior vena cava necessitated cardiopulmonary bypass and blood transfusion.
Post-transfusion, the patient experienced acute pulmonary edema (suspected TRALI) and retroperitoneal bleeding, leading to an inability to wean from bypass and eventual death.

Findings:

The case illustrates a rare instance of TRALI occurring during complex cardiac surgery with cardiopulmonary bypass.
Simultaneous severe pulmonary edema and retroperitoneal bleeding complicated management.
Inability to oxygenate due to pulmonary edema prevented anticoagulation reversal, exacerbating bleeding.

Implications:

This case underscores challenges in vascular access for cardiopulmonary bypass in specific surgical positions.
Recommendations include pre-cannulation of femoral vessels and considering direct right atrial access.
Adult extracorporeal membrane oxygenation may be a life-saving option for severe pulmonary edema unresponsive to other measures.