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Optimizing injectable poly-L-lactic acid administration for soft tissue augmentation: The rationale for three
1Clinica Diaz, Padova, Italy;
Summary
Injectable poly-L-lactic acid (PLLA) treatments for facial wrinkles and volume loss typically require an average of three sessions. This regimen optimizes collagen production for long-lasting results in most patients.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Biomaterials Science
Background:
- Soft tissue augmentation procedures have increased due to diverse injectable options.
- Injectable poly-L-lactic acid (PLLA) is FDA-approved for facial wrinkles and HIV-associated lipoatrophy.
- PLLA is a synthetic, biodegradable polymer used for facial contour correction.
Purpose of the Study:
- To review studies on injectable PLLA treatment protocols.
- To focus on recommended treatment session numbers and intervals.
- To support a three-session regimen with case studies.
Main Methods:
- Literature review of previous injectable PLLA studies.
- Analysis of treatment session frequency and timing.
- Presentation of two clinical case studies.
Main Results:
- PLLA injections stimulate cellular events leading to collagenesis and volume restoration.
- The response to PLLA is gradual, with long-lasting effects.
- Adequate intervals between sessions are crucial to prevent overcorrection.
Conclusions:
- Clinical studies support the proposed mechanism of action for PLLA.
- The authors recommend an average of three treatment sessions as optimal.
- This regimen is suitable for the majority of patients undergoing PLLA treatment.
