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Sleep, sleep-disordered breathing and lipid homeostasis: translational evidence from murine models and children

Rakesh Bhattacharjee1, Fahed Hakim, David Gozal

  • 1Department of Pediatrics, Pritzker School of Medicine, Comer Children's Hospital, University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K-160, Chicago, IL 60637, USA.

Clinical Lipidology
|September 4, 2012
PubMed

Insights

Sleep-disordered breathing (SDB) and obesity in children are linked. Disrupted sleep negatively impacts lipid homeostasis, potentially causing obesity in children.

Area of Science:

  • Pediatric Sleep Medicine
  • Metabolic Disorders
  • Obesity Research

Background:

  • Obesity is a growing global health concern, particularly in children.
  • Sleep-disordered breathing (SDB) is increasingly prevalent in pediatric populations.
  • The complex relationship between obesity and SDB, often described as a 'chicken and the egg' scenario, requires further elucidation.

Purpose of the Study:

  • To critically examine the impact of sleep disruption and SDB on lipid homeostasis.
  • To review evidence from both murine and human models.
  • To demonstrate that disrupted sleep in children may precede obesity through disordered lipid metabolism.

Main Methods:

  • Literature review of studies investigating sleep disruption, SDB, and lipid homeostasis.
  • Analysis of data from murine models of sleep disturbance and obesity.
  • Examination of human studies correlating sleep patterns, SDB, and metabolic profiles.

Main Results:

  • Sleep disruption and SDB are associated with significant alterations in lipid homeostasis.
  • Evidence suggests a convergence of obesity and SDB exacerbates disruptions in normal lipid metabolism.
  • Pediatric SDB and sleep fragmentation show a direct link to dysregulated lipid profiles.

Conclusions:

  • Disrupted sleep, especially SDB in children, is a significant factor contributing to disordered lipid homeostasis.
  • This disordered lipid metabolism serves as a potential precursor to childhood obesity.
  • Understanding this link is crucial for developing targeted interventions for pediatric obesity and SDB.

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