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Summary

This study presents a model for elastic pore sensors, enabling accurate particle size and velocity measurements. The pore sensor model accurately characterizes particle size and translocation dynamics under varying membrane stretch conditions.

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Elastic pore sensors offer tunable dimensions for particle analysis.
  • Understanding pore dimension changes with membrane stretch is crucial for sensor accuracy.

Purpose of the Study:

  • To develop an empirically derived model for elastic size-tunable pore sensor dimensions under applied membrane stretch.
  • To enable accurate calculation of particle size and translocation velocity profiles from sensor 'pulse' events at any membrane stretch.

Main Methods:

  • Developed an empirical model for pore dimension changes with membrane stretch.
  • Integrated this model with a simplified pore resistance model.
  • Analyzed particle 'pulse' events to determine size and velocity profiles.

Main Results:

  • Accurate size analysis of a trimodal particle suspension (220, 330, 410 nm) with low variance (<8.2%) and high size accuracy (<2.5% deviation from DLS).
  • Observed initial particle acceleration to 5,000-6,000 µm/s within the pore sensing zone.
  • Identified rapid particle deceleration due to pore geometry effects on electric field strength and fluid flow.

Conclusions:

  • The developed model accurately predicts pore dimension changes with membrane stretch.
  • The combined modeling approach allows for precise particle sizing and velocity determination.
  • Pore geometry significantly influences particle translocation dynamics within the sensor.