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Updated: May 19, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Colorectal carcinoma: Pathologic aspects.
Matthew Fleming1, Sreelakshmi Ravula, Sergei F Tatishchev
1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA.
Journal of Gastrointestinal Oncology
|September 4, 2012
Summary
Colorectal carcinoma (CRC) diagnosis relies on pathology. Molecular pathology is vital for personalized medicine, guiding patient management and prognosis for this common cancer.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Colorectal carcinoma (CRC) is a leading cause of cancer death in the US.
- Accurate diagnosis via pathologic examination of specimens is essential for patient care.
- Molecular testing is increasingly critical in personalized cancer medicine.
Purpose of the Study:
- To review the histopathology and molecular pathology of colorectal carcinoma.
- To discuss precursor lesions of colorectal cancer.
- To emphasize the clinical relevance of these pathologic findings.
Main Methods:
- Literature review of histopathology and molecular pathology in colorectal cancer.
- Focus on diagnostic criteria and molecular alterations.
- Integration of clinical relevance and patient management implications.
Main Results:
- Histopathology provides foundational diagnosis for colorectal cancer.
- Molecular pathology offers insights into tumor behavior and therapeutic targets.
- Understanding precursor lesions aids in early detection and prevention strategies.
Conclusions:
- Comprehensive histopathologic and molecular evaluation is crucial for optimal colorectal cancer management.
- Personalized medicine approaches in CRC are driven by detailed molecular pathology.
- This review highlights the clinical significance of pathology in colorectal carcinoma.
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