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Updated: May 19, 2026

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
Published on: March 25, 2022
The expanding world of stem cell modeling of Huntington's disease: creating tools with a promising future
Jacqueline M Ward1, Albert R La Spada2
1Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0642, La Jolla, CA 92037, USA ; Institute for Genomic Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0642, La Jolla, CA 92037, USA ; Sanford Consortium for Regenerative Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0642, La Jolla, CA 92037, USA.
Abstract:
Deconstructing the mechanistic basis of neurodegenerative disorders, such as Huntington's disease (HD), has been a particularly challenging undertaking, relying mostly on post-mortem tissue samples, non-neural cell lines from affected individuals, and model organisms. Two articles recently published in Cell Stem Cell report first the generation and characterization of induced pluripotent stem cell (iPSC)-derived models for HD, and second, the genetic correction of a disease-causing CAG expansion mutation in iPSCs from individuals with HD. Taken together, these two studies provide a framework for the production and validation of iPSC materials for human neurodegenerative disease research and yield crucial tools for investigating future therapies.
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