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Updated: May 19, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
[Current approaches in neovascular glaucoma]
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. xiulan_z@yahoo.com
Abstract:
Neovascular glaucoma (NVG) has long been recognized as a very difficult case to manage for its very poor prognosis of visual function. NVG is also remarked as an 'end stage' of ocular diseases. Conventional treatments with extremely uncontrolled cases are retinal cryotherapy or enucleation. Currently, management of this medical condition is directed toward a new era with great advancement in diagnosis and treatment. Glaucoma drainage implant surgery brings a time window of normal range of intraocular pressure (IOP) for physicians to process underlying disease of NVG. Regression of iris neovascularization by employing panretinal photocoagulation (PRP) or intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) antibodies create a chance to undertaken antiglaucomatous surgery. Adjunctive anti-VEGF treatment promotes the surgical success rate for NVG. Current approaches in NVG are able to provide patients with an individualized management using a sound treatment strategy according to etiology, stage of disease, visual potential and other factors.
Insights
Neovascular glaucoma (NVG) management has improved with new treatments. Advances like glaucoma drainage implants and anti-VEGF therapies offer better intraocular pressure control and surgical success rates for this severe eye condition.
Area of Science:
- Ophthalmology
- Vascular Biology
Context:
- Neovascular glaucoma (NVG) is a severe, end-stage ocular disease with a poor visual prognosis.
- Traditional treatments like cryotherapy or enucleation are often employed for uncontrolled cases.
Purpose:
- To highlight advancements in the diagnosis and management of neovascular glaucoma.
- To discuss novel therapeutic strategies improving patient outcomes.
Summary:
- Modern NVG management involves glaucoma drainage implant surgery to normalize intraocular pressure (IOP).
- Regression of iris neovascularization is achieved via panretinal photocoagulation (PRP) or anti-vascular endothelial growth factor (anti-VEGF) injections.
- Adjunctive anti-VEGF treatment enhances surgical success rates in NVG.
Impact:
- Current approaches enable individualized treatment strategies for NVG based on disease factors.
- These advancements offer a better chance for preserving visual function in patients with NVG.
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