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Updated: May 19, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
Novel multimodality endoscopic closure of postoperative esophageal fistula
Sheraz R Markar1, Richard Koehler, Donald E Low
1Department of Thoracic Surgery, Virginia Mason Medical Center, Seattle, WA, USA.
Introduction:
Esophageal fistula following esophagectomy is associated with significant morbidity and mortality.
Presentation Of Case:
We present the case of a 71-year-old man who underwent salvage Ivor-Lewis esophagectomy, following definitive chemoradiotherapy 1 year previously. On postoperative day 9 the patient complained of chest pain, and a CT scan demonstrated extravasation of oral contrast from the gastric conduit into the right chest. A right chest drain and fully covered esophageal stent were placed at this time. Despite these measures, after 8 weeks, the esophageal fistula persisted. Ultimately, fistula closure was achieved using an interventional radiology-guided, endoscopically placed over-the-scope clip (OTSC). The patient had no further complications and was well at 3 months follow-up.
Discussion:
The case reported herein describes this novel, combined-modality approach to esophageal fistula closure.
Conclusion:
This case report demonstrates a novel, minimally invasive, multidisciplinary approach to the closure of a post-esophagectomy anastamotic leak.
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