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Related Experiment Video

Updated: May 19, 2026

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
07:55

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection

Published on: November 3, 2012

Herpes keratitis.

A M Rowe1, A J St Leger, S Jeon

  • 1University of Pittsburgh, Department of Ophthalmology, Pittsburgh, PA 15213, United States.

Progress in Retinal and Eye Research
|September 5, 2012
PubMed
Summary
This summary is machine-generated.

Herpes simplex virus-1 (HSV-1) causes herpes stromal keratitis (HSK), a recurring eye infection leading to vision loss. This review explores HSK

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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
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Last Updated: May 19, 2026

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07:55

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Published on: November 3, 2012

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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Area of Science:

  • Ophthalmology
  • Virology
  • Immunology

Background:

  • Herpes simplex virus-1 (HSV-1) is a widespread infection.
  • Ocular HSV-1 infections can lead to herpes stromal keratitis (HSK), a severe inflammatory eye disease.
  • HSK causes recurrent corneal scarring and visual impairment, with current treatments lacking targeted immunopathologic approaches.

Purpose of the Study:

  • To review the clinical epidemiology and pathology of HSK.
  • To summarize current basic research on HSK immunopathology.
  • To identify knowledge gaps in understanding HSK pathogenesis and recurrence.

Main Methods:

  • Literature review of clinical epidemiology and pathology of HSK.
  • Summary of basic research on the immunopathology of HSK.
  • Examination of innate and adaptive immune system roles in HSK.

Main Results:

  • HSK is an immunoinflammatory condition associated with HSV-1 ocular infections.
  • Recurrent HSK leads to progressive corneal scarring and vision impairment.
  • Current therapies rely on broad immunosuppression and antivirals, with limited translation from animal models.

Conclusions:

  • A comprehensive understanding of HSK immunopathology is crucial for developing improved therapies.
  • Further research is needed to elucidate the mechanisms of viral clearance and corneal destruction in HSK.
  • Targeting specific immune pathways may offer new therapeutic strategies for recurrent HSK.