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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
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Published on: September 22, 2020

[Subintimal angioplasty for chronic arterial occlusive disease: a systematic review]

Xiang-xiang Li1, Xin-wu Lu, Kai-chuang Ye

  • 1Department of Vascular Surgery, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, China.

Zhonghua Yi Xue Za Zhi
|September 5, 2012
PubMed

Insights

Subintimal angioplasty effectively treats chronic lower extremity arterial occlusive disease, offering high limb salvage and low complications. Selective re-entry device use and anti-platelet drugs significantly improve outcomes.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Endovascular Therapy

Background:

  • Chronic arterial occlusive disease of the lower extremity significantly impacts patient mobility and quality of life.
  • Endovascular interventions are increasingly utilized for treating peripheral artery disease.

Purpose of the Study:

  • To evaluate the clinical effectiveness of subintimal angioplasty for chronic lower extremity arterial occlusive disease.
  • To assess technical success, primary patency, limb salvage, and complication rates.

Main Methods:

  • A meta-analysis of 14 studies involving 2350 patients with lower extremity arterial occlusive disease.
  • Systematic review of electronic databases and cross-referencing for eligible studies.
  • Data extraction and quality assessment by three independent reviewers.

Main Results:

  • Technical success rates were 96.4% with re-entry catheters versus 87% without (P < 0.01).
  • Limb salvage rates were 90.5% at 6 months and 81.5% at 12 months.
  • Primary patency rates were 91% at 6 months with anti-platelet drugs versus 68.5% without (P < 0.01); overall complication rate was 8.25%.

Conclusions:

  • Subintimal angioplasty is a safe and effective treatment for chronic lower extremity arterial occlusive disease.
  • Selective use of re-entry devices and preoperative anti-platelet medication enhance procedural success.
  • Further randomized trials and long-term follow-up are needed to confirm efficacy.
Abstract

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