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Electrospun poly(lactic acid)/chitosan core-shell structure nanofibers from homogeneous solution.

Yajing Li1, Fan Chen, Jun Nie

  • 1State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Carbohydrate Polymers
|September 5, 2012
PubMed
Summary

Researchers developed simple electrospun poly(lactic acid)/chitosan nanofibers with a core-shell structure. These biocompatible nanofibers promote cell growth, showing potential for tissue engineering and wound healing applications.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Tissue Engineering

Background:

  • Developing advanced materials for tissue regeneration is crucial.
  • Poly(lactic acid) (PLA) and chitosan are biocompatible polymers with potential in biomedical applications.
  • Core-shell nanofibers offer unique properties for drug delivery and tissue scaffolding.

Purpose of the Study:

  • To fabricate poly(lactic acid)/chitosan (PLA/chitosan) core-shell nanofibers using a simple and effective electrospinning method.
  • To characterize the morphology, structure, and composition of the fabricated nanofibers.
  • To evaluate the in vitro biocompatibility and potential applications of the nanofibers in tissue engineering and wound healing.

Main Methods:

  • Homogeneous solution electrospinning of PLA/chitosan mixtures at various weight ratios.

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  • Characterization using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and energy dispersive spectrometer (EDS).
  • In vitro cell culture studies using mouse fibroblasts (L929) to assess cell attachment and proliferation.

    • Main Results:

    • Successfully fabricated PLA/chitosan core-shell nanofibers via a simplified electrospinning process.
    • Confirmed the core-shell structure with PLA in the core and chitosan in the shell, attributed to phase separation.
    • Demonstrated excellent cell attachment and proliferation of L929 fibroblasts on the nanofibrous membranes.

    Conclusions:

    • The developed single-step electrospinning method is efficient for producing PLA/chitosan core-shell nanofibers.
    • The core-shell nanofibers exhibit good biocompatibility, promoting fibroblast growth and attachment.
    • These PLA/chitosan nanofibers are promising candidates for applications in tissue engineering and as wound healing dressings.