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Updated: May 19, 2026

Analyzing Responses of Mouse Olfactory Sensory Neurons Using the Air-phase Electroolfactogram Recording
Published on: March 2, 2010
Recording odor-evoked response potentials at the human olfactory epithelium
1Department of Neurobiology, Hebrew University of Jerusalem, Israel. hadas.lapid@gmail.com
Electro-olfactogram (EOG) measures olfactory receptor neuron responses. This review explores its use in human olfaction research, detailing methods, limitations, and potential for studying the peripheral olfactory system.
Area of Science:
- Neuroscience
- Sensory Physiology
Background:
- The electro-olfactogram (EOG) records olfactory receptor neuron activity.
- EOG is widely used in animal studies but less so in human research.
Purpose of the Study:
- To review the structure and function of the olfactory epithelium.
- To summarize EOG characteristics, conventions, and limitations in human olfaction research.
Main Methods:
- Overview of olfactory epithelium.
- Summary of EOG methodology, including pitfalls and artifacts.
- Discussion of current debates in the field.
Main Results:
- EOG provides direct measurement of peripheral olfactory system neuronal input.
- Simultaneous psychophysical responses can be obtained in awake humans.
Conclusions:
- EOG offers a unique method for investigating human olfactory perception.
- Further research is needed to overcome methodological challenges and fully utilize EOG in humans.
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