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Published on: November 10, 2023
The long-term outcomes of pediatric pleural empyema: a prospective study
Eyal Cohen1, Sanjay Mahant, Sharon D Dell
1Pediatric Outcomes Research Team (PORT), Division of Pediatric Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Canada. eyal.cohen@sickkids.ca
Insights
Pediatric pleural empyema outcomes show short-term symptoms, but most children recover fully. Long-term follow-up reveals minimal lasting effects in pediatric pleural empyema patients.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Thoracic Surgery
Background:
- Pediatric pleural empyema is a serious infection requiring prompt management.
- Understanding long-term outcomes is crucial for patient care and resource allocation.
Purpose of the Study:
- To describe the long-term clinical outcomes of pediatric pleural empyema.
- To assess respiratory symptoms, functional status, and quality of life post-treatment.
Main Methods:
- Prospective observational study of children with pleural empyema.
- Follow-up at 1, 6, and 12 months post-discharge.
- Outcome measures included clinical assessment, spirometry, and quality of life surveys (Pediatric Quality of Life Inventory).
Main Results:
- Most children (93%) were recruited, with data available up to 1 year.
- Short-term symptoms (fever, cough) and radiographic abnormalities were common but declined.
- By the last observation, few patients had abnormal radiographs (2%) or spirometry (6%), with improved quality of life scores.
Conclusions:
- Short-term clinical sequelae are common in pediatric pleural empyema.
- However, the vast majority of children experience no significant long-term adverse outcomes.
Objective:
To describe the long-term outcomes of pediatric pleural empyema.
Design:
Prospective observational study from October 2008 to October 2011.
Setting:
Tertiary care children's hospital.
Participants:
Children with pleural empyema (loculations and/or septations identified on radiologic imaging or frank pus on thoracentesis).
Main Outcome Measures:
Children were seen 1, 6, and 12 months postdischarge. Outcome measures included symptoms and signs of respiratory disease, child and parental impact, radiographic resolution, spirometry, and health-related quality of life (Pediatric Quality of Life Inventory score). Analysis was based on the last observation carried forward for missing data.
Results:
Eighty-two of 88 patients (93%) eligible were recruited. Fifty-four percent were male and mean (SD) age was 4.5 (3.4) years. Outcome data was obtained in 100% at 1 month, 90% at 6 months, and 72% at 1 year. Seventy-one percent had effusions occupying a quarter or more of the hemithorax and 62% of effusions were drained. Fever, cough, parental work loss, child school loss, radiographic abnormalities, and abnormal spirometry results were common in the first month and then declined. By the last observation, 2% of patients had abnormal radiographs (aside from pleural thickening), 6% had mild obstruction on spirometry, and Pediatric Quality of Life Inventory scores were better than for children with asthma (P < .001). Patients with abnormal outcomes in 1 measure had normal outcomes in all other clinical measures.
Conclusions:
Clinically important phenomena persist in the short-term, but virtually all children with pleural empyema have no long-term sequelae.
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