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Related Concept Videos

Tactile and Chemical Senses01:27

Tactile and Chemical Senses

Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex. This...
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Introduction to Special Senses01:26

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive functions.
Sensory Perception: Organization of the Somatosensory System01:11

Sensory Perception: Organization of the Somatosensory System

The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
Sensory Modalities01:15

Sensory Modalities

Sensation typically is the process by which the sensory receptors and sense organs detect stimuli from the internal and external environment and transmit this information to the central nervous system for processing.
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...

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Related Experiment Video

Updated: May 19, 2026

Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin
07:51

Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin

Published on: December 30, 2025

A cellular sense of touch.

Li He1, Denise Montell

  • 1Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. lihe@genetics.med.harvard.edu

Nature Cell Biology
|September 5, 2012
PubMed
Summary
This summary is machine-generated.

Researchers studied how cells respond to physical forces using fruit flies. They found that changing mechanical force affects the stability of integrin adhesion within living organisms.

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Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
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Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans

Published on: March 15, 2019

Related Experiment Videos

Last Updated: May 19, 2026

Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin
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Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin

Published on: December 30, 2025

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
04:27

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans

Published on: March 15, 2019

Area of Science:

  • Cellular biology
  • Biophysics
  • Mechanobiology

Background:

  • Cellular responses to physical forces are crucial for development and disease.
  • Investigating these responses in vivo presents significant experimental challenges.
  • Integrin adhesion complexes play key roles in sensing and transmitting mechanical signals.

Purpose of the Study:

  • To investigate how mechanical forces modulate integrin adhesion stability in vivo.
  • To explore the dynamics of integrin complexes under altered mechanical conditions.
  • To provide in vivo evidence for force-dependent regulation of cell adhesion.

Main Methods:

  • Utilized Drosophila melanogaster (fruit fly) as a model organism.
  • Analyzed the dynamics of integrin complexes.
  • Manipulated mechanical forces acting on cells in vivo.

Main Results:

  • Demonstrated that altering mechanical force directly impacts integrin adhesion stability.
  • Provided in vivo evidence for the modulation of integrin complex dynamics by physical forces.
  • Established a link between mechanical force and the stability of cellular adhesion.

Conclusions:

  • Mechanical force is a critical regulator of integrin adhesion stability in vivo.
  • Integrin complexes are sensitive to mechanical cues in a living organism.
  • This study offers new insights into mechanotransduction and cell adhesion.