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Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation
09:01

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

Thrombolytic evacuation of intracerebral and intraventricular hemorrhage

Mahua Dey1, Agnieszka Stadnik, Issam A Awad

  • 1Hemorrhagic Stroke Research Unit, Section of Neurosurgery, University of Chicago Medicine and Biological Sciences, IL 60637, USA.

Current Cardiology Reports
|September 5, 2012
PubMed

Insights

Minimally invasive surgery combined with thrombolytics shows promise for treating intracranial hemorrhage (ICH) and intraventricular hemorrhage (IVH). Larger trials are underway to confirm the therapeutic benefits of this approach for stroke patients.

Area of Science:

  • Neurology
  • Neurosurgery
  • Vascular Medicine

Background:

  • Intracranial hemorrhage (ICH) is a severe stroke type with high mortality and cost.
  • ICH prevalence significantly increases with age.
  • Traditional open surgical evacuation has shown limited benefit for ICH.

Purpose of the Study:

  • To review the background of minimally invasive surgery (MIS) for ICH.
  • To discuss the use of thrombolytics in ICH and intraventricular hemorrhage (IVH).
  • To highlight early findings from MISTIE and CLEAR trials.

Main Methods:

  • Review of existing literature on MIS and thrombolytics for ICH/IVH.
  • Analysis of early results from the MISTIE and CLEAR clinical trials.

Main Results:

  • Small trials suggest encouraging results for MIS with thrombolytics in ICH.
  • Early findings from MISTIE (ICH) and CLEAR (IVH) trials are being evaluated.

Conclusions:

  • Minimally invasive hematoma evacuation with thrombolytics presents a promising therapeutic strategy.
  • Larger clinical trials are essential to optimize and define the benefits of MIS and thrombolysis for ICH and IVH.

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