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Early recurrence after curative resection in oligonodular hepatocellular carcinoma
Liang Huang1, Jing Li, Jianjun Yan
1Department of Hepatic Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Background/Aims:
Often patients experience an unexpected early recurrence after hepatectomy for multinodular HCC. We conducted this retrospective study to observe the recurrence rate within 1 year after hepatectomy for oligonodular HCC (2 or 3 nodules) and investigate the risk factors for early recurrence.
Methodology:
The study population consisted of 102 patients with 2 or 3 HCCs that received curative resection between January 2009 and December 2009. Clinicopathological data were collected and subjected to univariate and multivariate analysis.
Results:
Forty-three (42.2%) patients were diagnosed as with recurrence within 1 year after hepatectomy. According to univariate analysis, the risk factors for early recurrence were alpha-fetoprotein (AFP) >200 ng/mL, microvascular involvement and lack of complete tumor capsule; microvascular involvement was an independent predictive factor for early recurrence by multivariate analysis (HR, 4.02; 95% CI, 1.42-11.39, p=0.009).
Conclusions:
There was a high rate of early recurrence for patients with oligonodular HCC (2 or 3 nodules) after hepatectomy. Microvascular involvement was an independent predictive factor for early recurrence, and adjuvant therapy, such as TACE, may be considered for those patients af
