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Related Concept Videos

DNA Packaging00:58

DNA Packaging

Overview
DNA Packaging00:58

DNA Packaging

Overview
Chromatin Packaging01:32

Chromatin Packaging

Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
Chromatin Packaging02:21

Chromatin Packaging

Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
Chromatin Packaging02:21

Chromatin Packaging

Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

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Related Experiment Video

Updated: May 19, 2026

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos
10:35

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

Published on: October 3, 2018

Packaging the fly genome: domains and dynamics.

Rob White1

  • 1Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. rw108@cam.ac.uk

Briefings in Functional Genomics
|September 5, 2012
PubMed
Summary

Two genomic methods reveal similar domain organization in the Drosophila genome. Mapping chromatin states and interactions defines structural domains, linking genome organization to gene activity.

Area of Science:

  • Genomics
  • Molecular Biology
  • Epigenetics

Background:

  • The genome is organized into functional domains.
  • Understanding this organization is key to understanding gene regulation.

Purpose of the Study:

  • To review current understanding of Drosophila genome domain architecture.
  • To explore the link between chromatin organization and genome activity.

Main Methods:

  • Genome-wide mapping of chromosomal proteins and histone modifications.
  • Whole genome mapping of chromatin interactions.

Main Results:

  • Identification of distinct chromatin states and their distribution into domains.
  • Discovery of genome segmentation into structural domains.

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Last Updated: May 19, 2026

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Published on: October 3, 2018

One-step CRISPR-based Strategy for Endogenous Gene Tagging in Drosophila melanogaster
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  • Convergence of two independent genomic approaches on similar domain organization.

    • Conclusions:

    • The Drosophila genome exhibits a defined domain architecture.
    • This architecture is revealed by chromatin mapping and interaction studies.
    • Domain organization provides a framework for understanding genome dynamics.