Synthesis, antifungal evaluation and molecular docking studies on 2- thioxoimidazolidin-4-one derivatives

A series of 2-thioxoimidazolidin-4-one derivatives were synthesized and were characterized by IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. All compounds were tested for antifungal and antibacterial activity. Some of the compounds were found to exhibit promising antifungal activity. Molecular modeling investigations showed that the active compounds may interact at the active site of the fungal cytochrome P450- dependent sterol 14α- demethylase in the sterol biosynthesis pathway.