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Related Experiment Video

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Application of nanofluids to microsphere generation using MEMS technology.

Ki-Young Song1, Wen-Jun Zhang

  • 1Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, S7N5A9.

Recent Patents on Nanotechnology
|September 6, 2012
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Summary
This summary is machine-generated.

This review explores microsphere generation using nanofluids for drug delivery, highlighting polymer microspheres for protecting protein drugs. It examines four microfluidic systems and future research opportunities.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Polymer-based microspheres are crucial for protecting protein-based drugs and enabling targeted delivery.
  • Microsphere generation is a key application of nanofluids in advanced drug delivery systems.
  • Existing literature and patents provide a foundation for understanding current microsphere generation technologies.

Purpose of the Study:

  • To review the research and development status of microsphere generation for drug delivery.
  • To analyze various microfluidic systems employed in microsphere fabrication.
  • To identify current advancements and future research directions in this field.

Main Methods:

  • Literature and patent review of microsphere generation techniques.
  • Analysis of four distinct microfluidic systems: membrane emulsification with cross flow, T-junction, hydrodynamic flow focusing, and chopper.
  • Evaluation of the state-of-the-art in microsphere generation technology.

Main Results:

  • Identified polymer-based microspheres as vital for drug protection and site-specific delivery.
  • Detailed the operational principles and applications of four microfluidic systems for microsphere generation.
  • Assessed the current technological landscape and developmental progress in the field.

Conclusions:

  • Microfluidic systems offer advanced capabilities for controlled microsphere generation in drug delivery.
  • Further research is needed to optimize existing systems and explore novel approaches for enhanced drug delivery.
  • The development of microsphere generation technology holds significant promise for the future of pharmaceutical applications.