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Immunomodulating therapy in liver transplantation: principles and practice.
Jody C Olson1, Russell H Wiesner
1Division of Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Immunotherapy
|September 6, 2012
Summary
Liver transplantation is a successful treatment for chronic liver diseases, genetic conditions, and liver cancer. Advances in surgery, critical care, and immunosuppressive therapies have significantly improved patient and graft survival.
Area of Science:
- Hepatology
- Transplant Surgery
- Immunology
Background:
- Liver transplantation is a life-saving treatment for end-stage liver disease, certain genetic disorders, and select liver cancers.
- Over 50,000 individuals currently live with functioning liver transplants worldwide.
- Success is attributed to surgical, anesthetic, and critical care advancements, alongside managing post-transplant complications like cytomegalovirus infections.
Purpose of the Study:
- To highlight the critical role of improved understanding in transplant immunology.
- To emphasize the impact of novel immunosuppressive agents on transplant outcomes.
- To underscore the advancements driving the success of liver transplantation.
Main Methods:
- Review of surgical techniques and critical care improvements.
- Analysis of advancements in managing post-transplant complications.
- Examination of progress in transplant immunology and immunosuppressive therapies.
Main Results:
- Significant increases in both graft and patient survival rates.
- Enhanced management of post-transplant complications.
- Successful treatment of diverse conditions including chronic liver disease, familial amyloidosis, primary oxalosis, and primary liver cancer.
Conclusions:
- Liver transplantation is a highly successful therapeutic option.
- Advances in immunosuppressive therapy are paramount to improved outcomes.
- Continued research in transplant immunology promises further enhancements in patient survival and graft function.
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