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Recovery from end-stage renal disease.

M A Sekkarie1, F K Port, R A Wolfe

  • 1School of Medicine, University of Michigan, Michigan Kidney Registry, Ann Arbor.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|January 1, 1990
PubMed
Summary
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Renal function recovery is possible in some end-stage renal disease (ESRD) patients, particularly those with specific conditions. Factors like race, age, and cause of ESRD influence recovery rates, highlighting the need for careful diagnosis.

Area of Science:

  • Nephrology
  • Renal Medicine
  • Epidemiology

Background:

  • End-stage renal disease (ESRD) diagnosis often implies irreversible kidney damage.
  • Assessing the potential for renal function recovery in ESRD patients is crucial for treatment planning.

Purpose of the Study:

  • To determine the rate of renal function recovery in patients diagnosed with ESRD.
  • To identify factors associated with renal function recovery in ESRD patients.

Main Methods:

  • Utilized the Michigan Kidney Registry database (1976-1985).
  • Analyzed data from 7,404 patients initiating ESRD treatment, excluding acute tubular necrosis and transplantation.
  • Evaluated recovery rates based on etiology, demographics, and dialysis modality.

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Main Results:

  • Recovery rates varied significantly by ESRD etiology; glomerulonephritis with systemic illness, vasculopathies, and crescents showed higher rates.
  • White race, older age, and later year of ESRD diagnosis were linked to increased recovery.
  • Approximately 48% of recovering patients regained function within 6 months, 74% within 1 year.

Conclusions:

  • Caution is advised when diagnosing ESRD due to potential for renal function recovery.
  • Proactive assessment for recovery is recommended, especially before considering early renal transplantation.
  • Understanding factors influencing recovery can refine prognoses and treatment strategies.