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Updated: May 19, 2026

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
Published on: November 19, 2012
An elegant technique for ex vivo imaging in experimental research-Optical coherence tomography (OCT)
T Tschernig1, L Thrane, T M Jørgensen
1Institute of Anatomy and Cell Biology, Saarland University, Homburg, Saar, Germany. thomas.tschernig@uks.eu
Abstract:
Optical coherence tomography (OCT) is an elegant technology for imaging of tissues and organs and has been established for clinical use for around a decade. Thus, it is used in vivo but can also serve as a valuable ex vivo imaging tool in experimental research. Here, a brief overview is given with a focus on an ex vivo application of OCT. Image and video examples of freshly obtained murine lungs are included. The main advantage of OCT for ex vivo analysis is the non-contact, non-invasive, and non-destructive fast acquisition of a three-dimensional data set with micrometer-resolution.
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