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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Related Experiment Video

Updated: May 19, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Morbidity and mortality associated with Clostridium difficile ribotype 078: a case-case study.

L Patterson1, M H Wilcox, W N Fawley

  • 1Public Health Agency, Health Protection Division, Belfast, UK. lynsey.patterson@hscni.net

The Journal of Hospital Infection
|September 6, 2012
PubMed
Summary
This summary is machine-generated.

Clostridium difficile ribotype 078 is linked to recent healthcare exposure. While not statistically significant, this strain showed trends towards community origins and lower mortality compared to ribotype 027.

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Related Experiment Videos

Last Updated: May 19, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Clostridium difficile infection (CDI) poses a significant public health threat.
  • Specific Clostridium difficile ribotypes, such as 027 and 078, are associated with outbreaks and varying clinical outcomes.
  • Understanding the epidemiology and clinical characteristics of emerging strains like ribotype 078 is crucial for effective control.

Purpose of the Study:

  • To compare the clinical and epidemiological features of Clostridium difficile ribotype 078 with other known outbreak strains.
  • To investigate factors associated with Clostridium difficile ribotype 078 acquisition and patient outcomes.
  • To generate hypotheses regarding the unique profile of Clostridium difficile ribotype 078.

Main Methods:

  • Retrospective analysis comparing Clostridium difficile ribotype 078 cases with a control group (e.g., ribotype 027).
  • Examination of patient demographics, healthcare exposure history, and clinical outcomes (morbidity, mortality).
  • Statistical analysis to determine significant differences between ribotypes.

Main Results:

  • A healthcare interaction within eight weeks of a positive specimen significantly increased the likelihood of Clostridium difficile ribotype 078 detection compared to ribotype 027.
  • Individuals with ribotype 078 tended to originate from community sources.
  • Hospital stay post-specimen and 30-day mortality showed non-significant trends towards similarity with ribotype 027 and lower mortality, respectively.

Conclusions:

  • Healthcare exposure is a significant risk factor for Clostridium difficile ribotype 078 infection.
  • Clostridium difficile ribotype 078 may have a distinct epidemiological profile, potentially with community origins.
  • Further research is warranted to elucidate the unique characteristics and clinical impact of Clostridium difficile ribotype 078.