Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nodulo-Infiltrative Subtype of Basal Cell Carcinoma With Follicular and Sebaceous Differentiation.

Cureus·2026
Same author

Interdisciplinary Management of Squamous Cell Carcinoma of the Hand With Mohs Micrographic Surgery and Dermal Template Placement.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Leiomyosarcoma With Dedifferentiation Mimicking a Benign Neoplasm.

The American Journal of dermatopathology·2026
Same author

Subcutaneous Chromoblastomycosis Caused by Rhinocladiella Species in Rhode Island.

Rhode Island medical journal (2013)·2025
Same author

Squamoid eccrine ductal carcinoma of the left thumb: A case report and review of treatment strategies.

JAAD case reports·2025
Same author

Classification of Kaposi Sarcoma Subtype in a Patient from Cape Verde.

Rhode Island medical journal (2013)·2025

Related Experiment Video

Updated: May 19, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Papillary dermal elastosis.

Annie R Wang, Leslie Robinson-Bostom

    Dermatology Online Journal
    |September 6, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Researchers re-evaluated a case initially diagnosed as papillary dermal elastosis. They propose it is more accurately classified as pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE).

    More Related Videos

    Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
    04:12

    Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

    Published on: December 19, 2019

    Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
    10:09

    Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

    Published on: February 28, 2013

    Related Experiment Videos

    Last Updated: May 19, 2026

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
    05:39

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

    Published on: May 16, 2025

    Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
    04:12

    Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

    Published on: December 19, 2019

    Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
    10:09

    Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

    Published on: February 28, 2013

    Area of Science:

    • Dermatopathology
    • Connective tissue disorders

    Background:

    • A previous report described papillary dermal elastosis (PDE) in 2009.
    • A recent article identified a second case of PDE.

    Discussion:

    • The histopathologic and clinical features of the reported case align more closely with pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE).
    • This suggests a potential reclassification of previously identified cases.

    Key Insights:

    • The distinction between PDE and PXE-PDE is crucial for accurate diagnosis.
    • Histopathological analysis is key to differentiating these similar conditions.

    Outlook:

    • Further research is needed to fully understand the spectrum of PXE-PDE.
    • Clarifying diagnostic criteria will aid in future case identification and management.