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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
08:26

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Published on: October 19, 2021

FTO, RNA epigenetics and epilepsy.

Joie Rowles1, Morgan Wong, Ryan Powers

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Glendale, AZ, USA.

Epigenetics
|September 6, 2012
PubMed
Summary
This summary is machine-generated.

The FTO enzyme plays a role in RNA epigenetics and may influence epilepsy by regulating microRNAs (miRNAs). This research explores the connection between FTO, RNA modifications, and neurological disorders like epilepsy.

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Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Epigenetics

Background:

  • N(6)-methyladenosine (m(6)A) is a crucial RNA modification impacting gene expression.
  • The FTO enzyme demethylates m(6)A RNA and is abundant in the central nervous system (CNS).
  • MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation and are implicated in neurological disorders such as epilepsy.

Purpose of the Study:

  • To explore the potential functional association between FTO, RNA epigenetics, and epilepsy.
  • To highlight the role of m(6)A modification in miRNA processing and function within the context of neurological disorders.
  • To propose a regulatory mechanism involving FTO in epilepsy pathogenesis.

Main Methods:

  • Review and synthesis of recent literature on m(6)A RNA modifications, FTO enzyme, and miRNAs.
  • Analysis of the co-occurrence of m(6)A sites and miRNA binding sequences in 3'UTRs.
  • Discussion of the potential impact of FTO-mediated m(6)A demethylation on miRNA activity in neuronal function and epilepsy.

Main Results:

  • Recent studies reveal the significance of m(6)A RNA modifications in the transcriptome and RNA epigenetics.
  • FTO is a key demethylase for m(6)A RNA, with high expression in the CNS.
  • miRNAs, particularly those upregulated by neuronal activity, are linked to epileptogenesis and possess m(6)A consensus sites.

Conclusions:

  • FTO may regulate miRNA processing or function through m(6)A modification, impacting neuronal activity.
  • A functional link between FTO, RNA epigenetics, and epilepsy is proposed.
  • Further research into this association could offer new insights into epilepsy mechanisms and potential therapeutic targets.