Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastrinoma excision for cure. A prospective analysis.

T J Howard1, M J Zinner, B E Stabile

  • 1Department of Surgery, UCLA Center for the Health Sciences.

Annals of Surgery
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canadian Surgery Forum.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Bacterial ecology of hospital workers' facial hair: a cross-sectional study.

The Journal of hospital infection·2014
Same author

[Surgical volume. An American perspective].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2007
Same author

Radiology of small bowel obstruction: contemporary approach and controversies.

Abdominal imaging·2005
Same author

Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells.

Surgery·2004
Same author

What is the value of telerobotic technology in gastrointestinal surgery?

Surgical endoscopy·2003
Same journal

Real-world Safety and Performance of the Symani Surgical System® in Microsurgical Reconstructive Procedures: Primary Results from the PRIMO Study.

Annals of surgery·2026
Same journal

Revisiting Simultaneous Liver and Kidney Transplantation from Donors After Circulatory Death in the Era of Machine Perfusion Technologies: A US Nationwide Analysis of 10,687 Cases.

Annals of surgery·2026
Same journal

The International Medical Graduate Paradox.

Annals of surgery·2026
Same journal

Defining the Incremental Value of Endoscopic Ultrasound in Assessing Pancreatic Cystic Neoplasms.

Annals of surgery·2026
Same journal

Trends in Metabolic and Bariatric Surgery and GLP-1 Receptor Agonist Use Among Adolescents with Severe Obesity.

Annals of surgery·2026
Same journal

The Ambulatory Surgery Center Paradox: Why 60% of Surgeries Occur Where 2% of AI Research Happens.

Annals of surgery·2026
See all related articles

Surgical resection offers a high cure rate for gastrinoma, even with lymph node involvement. This prospective study shows improved outcomes compared to historical controls, clarifying surgery's role.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Endocrinology

Background:

  • The efficacy of surgical intervention for gastrinoma remains uncertain.
  • Gastrinoma, a neuroendocrine tumor, often presents diagnostic and therapeutic challenges.

Purpose of the Study:

  • To prospectively determine the surgical cure rate for gastrinoma.
  • To compare outcomes with a historical control group.

Main Methods:

  • A prospective clinical trial involving 11 patients undergoing surgical exploration and tumor resection for cure.
  • Comparison with a historical control group.
  • Defined cure criteria including normal gastrin levels, no secretin response, symptom absence off medication, and no recurrence.

Main Results:

Related Experiment Videos

  • Tumors were typically small, multiple, and located in lymph nodes within the gastrinoma triangle.
  • A significantly higher proportion of patients in the prospective group achieved a curative resection (82%) compared to controls (27%, p<0.05).
  • Tumor detection rate was high (91% in the study group).

Conclusions:

  • The prospective surgical cure rate for gastrinoma is higher than previously estimated.
  • Resection of gastrinomas with lymph node metastasis can be curative.
  • Surgery plays a vital role in achieving cure for patients with gastrinoma.