Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Riboswitch-targeted improvement of lysine production in Bacillus and Priestia species.

NPJ science of food·2026
Same author

Synthesis and Evaluation of <sup>68</sup>Ga-Labeled NT(6-13) Analogs Incorporating Non-Canonical Amino Acid Substitutions at Tyr<sup>11</sup> for Targeting NTSR1 in Various Solid Malignancies.

ACS omega·2026
Same author

Characterization of the virus-host RNA-RNA interactome across important human pathogenic RNA viruses.

PLoS pathogens·2026
Same author

Quantitative Autofluorescence Imaging of Oral Mucosa and Lesions: A Proof-of-Concept Study.

Diagnostics (Basel, Switzerland)·2026
Same author

The Reservoir Effect: Implications for Safety and Regulation of Long-acting Injectables in Psychiatric Care.

Recent advances in inflammation & allergy drug discovery·2026
Same author

Correction: New-Onset Tic Disorder Associated With Bupropion XL: A Rare Case.

Cureus·2026

Related Experiment Video

Updated: May 18, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Comparative ncRNA gene and structure prediction using Foldalign and FoldalignM.

Jakob Havgaard1, Simranjeet Kaur1, Jan Gorodkin1

  • 1Center for Non-Coding RNA in Technology and Health, Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.

Current Protocols in Bioinformatics
|September 6, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces Foldalign and FoldalignM for structural alignment of non-protein-coding RNAs (ncRNAs). These tools aid in discovering novel ncRNAs and refining structures of known ones.

More Related Videos

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
07:09

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Related Experiment Videos

Last Updated: May 18, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
07:09

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Non-protein-coding RNAs (ncRNAs) play crucial roles in cellular processes.
  • Accurate structural alignment is essential for understanding ncRNA function and evolution.
  • Existing methods may have limitations in aligning diverse ncRNA structures.

Purpose of the Study:

  • To describe the application of Foldalign and FoldalignM for structural alignment of ncRNAs.
  • To demonstrate the utility of these tools for ncRNA discovery and structure elucidation.
  • To provide a method for improving alignments of known ncRNAs.

Main Methods:

  • Utilizing Foldalign and FoldalignM software for RNA structural alignment.
  • Applying the tools to datasets of known and novel ncRNAs.
  • Evaluating the accuracy and efficiency of the alignment process.

Main Results:

  • Foldalign and FoldalignM enable effective structural alignment of ncRNAs.
  • The tools facilitate the identification of novel ncRNA candidates.
  • Structural alignments generated by these tools can enhance the understanding of ncRNA families.

Conclusions:

  • Foldalign and FoldalignM are valuable tools for ncRNA research.
  • These methods contribute to the discovery and characterization of ncRNAs.
  • Improved structural alignments can advance the study of ncRNA function and evolution.