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Localization of auditory response sources using magnetoencephalography and magnetic resonance imaging
A C Papanicolaou1, S Baumann, R L Rogers
1Division of Neurosurgery, University of Texas Medical Branch, Galveston 77550.
Archives of Neurology
|January 1, 1990
Summary
Magnetoencephalography accurately pinpoints brain activity sources. This study validates its reliability in localizing auditory cortex responses to sound stimulation across subjects.
Area of Science:
- Neuroscience
- Biophysics
Background:
- Magnetoencephalography (MEG) enables noninvasive localization of intracranial current sources.
- Understanding brain activity requires accurate source localization techniques.
Purpose of the Study:
- To assess the validity and reliability of magnetoencephalography for localizing cortical sources.
- To investigate source localization of auditory cortex responses to ipsilateral and contralateral auditory stimulation.
Main Methods:
- Measured magnetic evoked fields in eight healthy subjects during auditory stimulation.
- Estimated cortical sources of the magnetic fields.
- Projected source locations onto magnetic resonance images.
Main Results:
- Cortical sources were accurately localized near the auditory cortex in all subjects.
- Two distinct sources were identified for ipsilateral and contralateral auditory stimulation.
- Demonstrated high across-subject reliability for source localization.
Conclusions:
- Magnetoencephalography provides a valid and reliable method for localizing auditory cortex activity.
- Distinct neural sources underlie responses to ipsilateral and contralateral auditory stimuli.
- MEG is a valuable tool for studying functional neuroanatomy.