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Related Concept Videos

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Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Updated: May 18, 2026

Gastric Point of Care Ultrasound in Adults: Image Acquisition and Interpretation
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Gastric Point of Care Ultrasound in Adults: Image Acquisition and Interpretation

Published on: September 22, 2023

Hyperglobus, do not forget the sinister.

Aitor de Gea Rico1, Sat Parmar, Peter J Revington

  • 1Department of Oral and Maxillofacial Surgery, Frenchay Hospital, Bristol, Avon, UK. odontoaitor@hotmail.com

BMJ Case Reports
|September 6, 2012
PubMed
Summary
This summary is machine-generated.

A rare case of hyperglobus, an elevated ocular globe, was caused by a prostate carcinoma metastasis. This is the first reported instance of this specific condition in medical literature.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Hyperglobus is defined as an abnormal elevation of the ocular globe.
  • Orbital masses can cause globe displacement, but hyperglobus is a distinct presentation.
  • Prostate carcinoma commonly metastasizes to bone but rarely to the orbit.

Observation:

  • A patient presented with hyperglobus, a condition where the eyeball is pushed upward.
  • Imaging revealed a metastatic mass within the orbit.
  • Biopsy confirmed the mass originated from a primary prostate carcinoma.

Findings:

  • The metastatic prostate carcinoma was identified as the cause of hyperglobus in this patient.
  • This represents the first documented case of hyperglobus secondary to prostate cancer metastasis.
  • The majority of the bony orbit remained intact despite the intraorbital mass.

Implications:

  • This case expands the known clinical manifestations of prostate carcinoma metastasis.
  • It highlights the importance of considering unusual orbital presentations in patients with known or suspected prostate cancer.
  • Further research may be warranted to understand the mechanisms and frequency of such orbital metastases.