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Updated: May 18, 2026

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
Published on: February 10, 2014
Measurement of barrier tissue integrity with an organic electrochemical transistor
Leslie H Jimison1, Scherrine A Tria, Dion Khodagholy
1Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France.
Abstract:
The integration of an organic electrochemical transistor with human barrier tissue cells provides a novel method for assessing toxicology of compounds in vitro. Minute variations in paracellular ionic flux induced by toxic compounds are measured in real time, with unprecedented temporal resolution and extreme sensitivity.
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