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Related Experiment Video

Updated: May 18, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Epithelial-mesenchymal transitions: insights from development.

Jormay Lim¹, Jean Paul Thiery

¹Institute of Molecular Cell Biology, ASTAR, 61 Biopolis Drive, Singapore.

Development (Cambridge, England)

|September 6, 2012

Summary

Epithelial-mesenchymal transition (EMT) is a vital developmental process. Understanding EMT in embryonic development offers insights into cancer progression and metastasis.

Area of Science:

Developmental Biology
Cancer Biology
Cellular Biology

Background:

Epithelial-mesenchymal transition (EMT) is a fundamental biological process.
EMT is conserved across species and critical for embryonic development.
EMT is also implicated in cancer progression and metastasis.

Purpose of the Study:

To review the role of EMT in embryonic development.
To explore the molecular mechanisms underlying EMT.
To connect developmental EMT knowledge with cancer metastasis.

Main Methods:

Literature review of developmental EMT studies.
Analysis of molecular programs governing EMT.
Comparison of EMT mechanisms in development and cancer.

More Related Videos

Induction and Analysis of Epithelial to Mesenchymal Transition

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Published on: June 10, 2016

Related Experiment Videos

Last Updated: May 18, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Induction and Analysis of Epithelial to Mesenchymal Transition

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Published on: June 10, 2016

Main Results:

EMT is essential for embryonic morphogenesis (e.g., gastrulation, neural crest delamination, heart formation).
Molecular programs of developmental EMT are linked to cancer.
Insights from developmental EMT inform understanding of tumor metastasis.

Conclusions:

Developmental EMT processes provide a framework for understanding cancer.
Further research into EMT's molecular underpinnings is crucial for both fields.
EMT is a key target for therapeutic strategies in cancer.