Tooth shape formation and tooth renewal: evolving with the same signals
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Updated: May 18, 2026

Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal
Published on: October 27, 2023
Jukka Jernvall1, Irma Thesleff
1Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, FIN 00014, Finland. jernvall@fastmail.fm
Abstract:
Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for the study of epithelial organ development and evolution. Here, we review the developmental mechanisms underlying changes in tooth complexity and tooth renewal during evolution, focusing on recent studies of fish, reptiles and mammals. Mammals differ from other living vertebrates in that they have the most complex teeth with restricted capacity for tooth renewal. As we discuss, however, limited tooth replacement in mammals has been compensated for in some taxa by the evolution of continuously growing teeth, the development of which appears to reuse the regulatory pathways of tooth replacement.
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