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Updated: May 18, 2026
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Primary small cell neuroendocrine carcinoma of the endometrium
Lisa N Abaid1, John S Cupp, John V Brown
1Gynecologic Oncology Associates, Hoag Memorial Hospital Presbyterian, Newport Beach, Calif., USA.
Background:
Small cell neuroendocrine carcinoma is very rarely encountered within the endometrium.
Case Study:
A patient underwent a hysterectomy and salpingo-oophorectomy for a suspicious gynecologic condition. Pathology revealed invasive small cell neuroendocrine carcinoma of the endometrium; the neoplasm exhibited positive immunoreactivity for synaptophysin, pancytokeratin and CD56 but was negative for CD3 and CD20. Prior to chemotherapy, a completion lymphadenectomy was indicated to determine the presence of nodal metastases.
Conclusion:
The prognosis of small cell neuroendocrine carcinoma of the endometrium is unfavorable but prompt detection with surgery and adjuvant therapy may confer a better clinical outcome.
