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Updated: May 18, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Relationship between renal function and physical performance in elderly hospitalized patients.

Fabrizia Lattanzio¹, Andrea Corsonello, Angela Marie Abbatecola

¹Scientific Direction, Italian National Research Centre on Aging, Ancona, Italy.

Rejuvenation Research

|September 7, 2012

Summary

Reduced kidney function is linked to poorer physical performance in older hospitalized patients. The Short Physical Performance Battery (SPPB) can monitor physical function changes in elderly patients with chronic kidney disease (CKD).

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Area of Science:

Gerontology and Geriatric Medicine
Nephrology
Physical Medicine and Rehabilitation

Background:

Chronic kidney disease (CKD) is increasingly implicated in the decline of physical functioning among older adults.
While the Short Physical Performance Battery (SPPB) is reliable for assessing physical function in the elderly, data specific to hospitalized older patients with varying degrees of kidney function were lacking.

Purpose of the Study:

To investigate the association between estimated glomerular filtration rate (eGFR) and physical performance, as measured by the SPPB, in hospitalized older patients.
To examine the relationship between eGFR and the global SPPB score, as well as its individual components: muscle strength, balance, and walking speed.

Main Methods:

A multicenter observational study included 486 hospitalized patients aged 65 years or older.
Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI equation.
Physical performance was objectively assessed using the Short Physical Performance Battery (SPPB). Multiple linear regression analysis was employed to determine the relationship between eGFR and SPPB.

Main Results:

A significant independent association was found between eGFR and the SPPB total score, balance, and muscle strength.
Specifically, higher eGFR levels correlated with better performance in overall physical function, balance, and muscle strength.
No significant association was observed between eGFR and walking speed.

Conclusions:

Reduced kidney function is independently associated with poorer physical performance in older adults admitted to hospitals.
The SPPB is a valuable tool for monitoring physical performance changes in elderly patients diagnosed with chronic kidney disease (CKD).