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Updated: May 18, 2026
07:53
Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse
Published on: August 15, 2018
Gastric mucosal protection and central nervous system
Klara Gyires1, Jozsef Németh, Zoltan S Zádori
1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad ter 4., 1089, Budapest, Hungary. gyirkla@net.sote.hu
Current Pharmaceutical Design
|September 7, 2012
Summary
Central nervous system pathways, including the hypothalamus and dorsal vagal complex, regulate gastric mucosal integrity. Endogenous opioids like endomorphin-1 and endomorphin-2 show potent gastroprotective effects, highlighting their role in maintaining stomach lining health.
Area of Science:
- Gastroenterology
- Neuroscience
- Physiology
Background:
- Gastric mucosal integrity is crucial and maintained by peripheral and central mechanisms.
- Peripheral protection involves mucus, prostaglandins, and nitric oxide.
- Central regulation involves the hypothalamus and dorsal vagal complex (DVC).
Purpose of the Study:
- To investigate the role of central mechanisms, particularly neuropeptides and the vagal nerve, in gastroprotection.
- To explore the gastroprotective potential of endogenous opioids, endomorphin-1 and endomorphin-2.
Main Methods:
- Examined peripheral and central factors in mucosal protection.
- Investigated the role of the vagal nerve in both injury and protection.
- Administered endomorphin-1 and endomorphin-2 intracerebroventricularly in an ethanol-induced ulcer model.
- Assessed the impact of diprotin A on endomorphin degradation and gastroprotection.
- Measured levels of CGRP and somatostatin after endomorphin-2 administration.
Main Results:
- The vagal nerve plays a dual role, essential for both centrally and peripherally induced gastroprotection.
- Endomorphin-1 and endomorphin-2 demonstrated potent gastroprotective effects in ethanol-induced ulcers.
- Inhibiting endomorphin degradation enhanced gastroprotection.
- Endomorphin-2 administration restored CGRP and somatostatin levels in gastric mucosa.
Conclusions:
- Neuropeptides in the DVC and hypothalamus regulate gastric mucosal integrity.
- Centrally induced gastroprotection is largely vagal-dependent.
- Endogenous opioids are key players in maintaining gastric mucosal defense mechanisms.
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