Waldenström's macroglobulinemia-associated renal amyloidosis presenting as a solitary lung mass
Yuan-You Chung1, Chuan-Cheng Wang, Kuan-Ju Lai
1Nephrology Division, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.
Abstract:
A single nodular lesion can be observed in various pulmonary diseases, including cancer, tuberculosis, and fungal infection. Waldenström's macroglobulinemia (WM) usually occurs in older adults and involves the lymph nodes, bone marrow, and spleen. Respiratory tract involvement is very rare. We reported a case of WM-associated renal amyloidosis. The patient was admitted with the initial presentation as a single mass in the lung and progression to renal involvement.
Insights
Waldenström's macroglobulinemia rarely affects the respiratory tract. This case highlights a rare presentation of Waldenström's macroglobulinemia-associated renal amyloidosis, initially appearing as a solitary pulmonary nodule.
Area of Science:
- Pulmonary Medicine
- Hematology
- Nephrology
Background:
- Single pulmonary nodules are common findings with diverse etiologies, including malignancy and infection.
- Waldenström's macroglobulinemia (WM) is a rare lymphoproliferative disorder typically affecting older adults, primarily involving lymph nodes, bone marrow, and spleen.
- Respiratory tract involvement in WM is exceptionally uncommon.
Observation:
- A patient presented with a solitary lung mass as the initial clinical manifestation.
- The patient's condition progressed to involve renal complications.
Findings:
- The case describes Waldenström's macroglobulinemia-associated renal amyloidosis.
- This represents a rare instance of WM presenting with pulmonary and subsequent renal involvement.
Implications:
- This case underscores the importance of considering rare systemic diseases in the differential diagnosis of solitary pulmonary nodules.
- Highlights the potential for Waldenström's macroglobulinemia to manifest with extranodal involvement, specifically in the lungs and kidneys.
- Emphasizes the need for comprehensive evaluation in patients with unexplained pulmonary lesions and systemic symptoms.
