Microbial metabolism. Part 14. Isolation and bioactivity evaluation of microbial metabolites of resveratrol
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Wimal Herath1, Shabana Iqrar Khan, Ikhlas Ahmad Khan
1a National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi , University , MS 38677 , USA.
Abstract:
The fungi, Beauveria bassiana (ATCC 13144) and Penicillium chrysogenium (ATCC 9480) transformed resveratrol to resveratrol-3-O-sulphate. The former, in addition, gave 5-methoxyresveratrol-3-O-β-glucoside with the latter yielding 5-methoxyresveratrol-3-O-sulphate. The structures were established by spectroscopic methods. Evaluation of biological activity of metabolites through a series of mammalian cell based assays indicated that resveratrol tends to lose its anti-inflammatory, cytotoxic and anti-oxidant activities with the substitution of its hydroxyl groups.
