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Relationship of central and peripheral blood pressure to left ventricular mass in hypertensive patients

Francisco J Pérez-Lahiguera1, Enrique Rodilla, Jose A Costa

  • 1Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Sagunto, Valencia, España.

Revista Espanola De Cardiologia (English Ed.)
|September 7, 2012
PubMed

Insights

Twenty-four-hour ambulatory blood pressure, not central blood pressure, is more closely related to left ventricular mass in untreated hypertensive individuals. Ambulatory systolic blood pressure showed the strongest correlation with left ventricular mass index.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Cardiovascular Imaging

Background:

  • Left ventricular mass (LVM) is a key indicator of cardiovascular risk.
  • Hypertension is a primary driver of left ventricular hypertrophy (LVH).
  • Understanding the relationship between different blood pressure measurements and LVM is crucial for risk stratification.

Purpose of the Study:

  • To evaluate the association between central and peripheral blood pressure measurements and left ventricular mass.
  • To determine which blood pressure monitoring method best correlates with left ventricular mass in never-treated hypertensive patients.

Main Methods:

  • A cross-sectional study involving 392 never-treated hypertensive individuals.
  • Measurements included office, 24-hour ambulatory, and central blood pressure (applanation tonometry).
  • Left ventricular mass was assessed using echocardiography.

Main Results:

  • Twenty-four-hour ambulatory blood pressure showed a stronger relationship with left ventricular mass than office or central blood pressure.
  • Systolic blood pressure consistently demonstrated higher correlations than diastolic blood pressure across all measurement types.
  • Left ventricular mass index changes were most significantly influenced by variations in 24-hour systolic blood pressure.

Conclusions:

  • In untreated middle-aged hypertensive patients, 24-hour ambulatory blood pressure is a superior correlate of left ventricular mass compared to office or central readings.
  • Central blood pressure measurement did not improve the identification of patients with left ventricular hypertrophy in this cohort.
  • Ambulatory blood pressure monitoring may offer better insights into hypertensive cardiac remodeling.
Abstract

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